Cd276 Mouse Models

Why Model Cd276

Cd276 is the mouse ortholog of human CD276 and encodes B7-H3, a member of the B7 family of immune-regulatory cell-surface proteins. B7-H3 has been associated with modulation of T-cell responses, though its receptor and precise roles remain under study.

B7-H3 is overexpressed on several tumors with limited expression in many normal tissues, and B7-H3-directed antibodies, antibody–drug conjugates, and CAR T cells have been evaluated; clinical results have varied. Cd276-deficient mice are viable with altered responses in some disease models.

Model Applications

Humanized CD276 (B7-H3) models, in which the human protein replaces the mouse counterpart, have been used to evaluate B7-H3-targeted therapeutics, including antibody–drug conjugates and cell therapies, in defined experimental settings.

Custom Cd276 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics. Trends Pharmacol Sci. 2025. doi:10.1016/j.tips.2025.08.008
• Chapoval AI et al. B7-H3: a costimulatory molecule for T cell activation and IFN-γ production. Nat Immunol. 2001. doi:10.1038/85339

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd80 · Cd86 · Pdcd1lg2 · Vtcn1