Cd3e Mouse Models

Why Model Cd3e

Cd3e is the mouse ortholog of human CD3E and encodes the CD3ε subunit of the T-cell receptor–CD3 complex. CD3ε contributes to assembly and surface expression of the complex and to transmission of T-cell-receptor signals.

CD3ε is the engagement point for T-cell-redirecting bispecific antibodies (T-cell engagers) used in several cancers, and anti-CD3 antibodies have other clinical uses; effects depend on the specific agent and context. Loss of CD3ε function has been associated with impaired T-cell development.

Model Applications

Humanized CD3E models, in which the human subunit replaces the mouse counterpart, have been used to evaluate T-cell-engaging bispecific antibodies in immunocompetent mice, often combined with humanization of a tumor-target antigen.

Cd3e models have been used to study T-cell-receptor signaling in defined experimental settings.

Custom Cd3e Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Navigating tarlatamab and bispecific T-cell engager therapy in small cell lung cancer: a narrative review. Cancer Treat Res Commun. 2026. doi:10.1016/j.ctarc.2026.101360
• Gold DP et al. Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature. 1986. doi:10.1038/321431a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd3d · Cd3g · Cd247 · Trac