CD44 Mouse Models

Why Model CD44

Cd44 is the mouse ortholog of human CD44 and encodes CD44, a cell-surface glycoprotein and a principal receptor for hyaluronan, expressed as multiple isoforms. CD44 has been associated with cell adhesion, migration, and signaling.

CD44, including certain variant isoforms, has been associated with cancer-stem-cell properties and drug resistance in several tumors, and CD44-directed approaches are under study. Cd44-deficient mice are viable with altered hematopoietic and inflammatory responses.

Model Applications

Humanized CD44 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD44-directed agents in defined experimental settings.

Custom CD44 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• CD44 overexpression as a mediator of drug resistance in oral cancer: a meta-analysis unveiling molecular underpinnings and therapeutic implications. Discov Oncol. 2025. doi:10.1007/s12672-025-03436-9
• Goldstein LA et al. A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell. 1989. doi:10.1016/0092-8674(89)90639-9

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Hmmr · Hyal1 · Spp1 · Sell