Cd47 Mouse Models

Why Model Cd47

Cd47 is the mouse ortholog of human CD47 and encodes CD47 (integrin-associated protein), a widely expressed cell-surface protein. CD47 binds the myeloid receptor SIRPα and has been associated with a signal that limits macrophage phagocytosis, sometimes described as a ‘don’t-eat-me’ signal.

CD47 overexpression on tumor cells has been associated with evasion of macrophage clearance in some contexts, and CD47-SIRPα-targeted agents have been evaluated in cancer; reported clinical results have varied. Cd47-deficient mice are viable and show altered clearance of circulating cells.

Model Applications

Humanized CD47 models, often combined with SIRPα humanization, have been used to evaluate CD47-SIRPα-targeted therapeutics and to support engraftment of human cells.

Cd47 knockout mice have been used to study macrophage regulation in defined experimental settings.

Custom Cd47 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Targeting the CD47/SIRPα pathway in malignancies: recent progress, difficulties and future perspectives. Front Oncol. 2024. doi:10.3389/fonc.2024.1378647
• Jaiswal S et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009. doi:10.1016/j.cell.2009.05.046

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Sirpa · Thbs1 · Itgav · Sirpg