CD5 Mouse Models

Why Model CD5

Cd5 is the mouse ortholog of human CD5 and encodes CD5, a scavenger-receptor-cysteine-rich family glycoprotein expressed on T cells and a subset of B cells. CD5 has been associated with modulation of antigen-receptor signaling.

CD5 is expressed on several T-cell malignancies, and CD5-directed CAR T cells are under study. Cd5-deficient mice are viable with altered lymphocyte responses.

Model Applications

Humanized CD5 models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD5-directed therapeutics in defined experimental settings.

Custom CD5 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial. Nat Med. 2024. doi:10.1038/s41591-024-03282-2
• Jones NH et al. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. Nature. 1986. doi:10.1038/323346a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cd6 · Cd5l · Ptprc · Lck