CLDN6 Mouse Models
| Field | Value |
|---|---|
| Mouse symbol | Cldn6 |
| Human ortholog | CLDN6 |
| Aliases | claudin-6 |
| Protein class | Tight-junction claudin (oncofetal antigen) |
| Location (human) | 16p13.3 |
| Mouse gene (MGI) | MGI:1859284 |
| Human gene | HGNC:2048 · NCBI Gene 9074 |
Why Model CLDN6
Cldn6 is the mouse ortholog of human CLDN6 and encodes claudin-6, a tight-junction membrane protein of the claudin family. Claudin-6 has been associated with epithelial barrier formation and is expressed during development.
Claudin-6 shows limited expression in most normal adult tissues and re-expression in several tumors, which has made it a target of CAR T-cell and antibody approaches under study. Mice with altered Cldn6 expression show epithelial barrier changes.
Model Applications
Humanized CLDN6 models, in which the human protein replaces the mouse counterpart, have been used to evaluate claudin-6-directed therapeutics in defined experimental settings.
Custom CLDN6 Model Options
Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.
- Conventional knockout
- Conditional knockout
- Point mutation / knockin
- Reporter knockin
- Humanized
- Targeted transgenic
Sources
- Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review). Int J Mol Med. 2024. doi:10.3892/ijmm.2024.5424
- Turksen K, Troy TC. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development. 2002. doi:10.1242/dev.129.7.1775
Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele
Related gene targets: Cldn3 · Cldn4 · Cldn9 · Cldn18
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