CLEC9A Mouse Models

Why Model CLEC9A

Clec9a is the mouse ortholog of human CLEC9A and encodes CLEC9A (DNGR-1, CD370), a C-type lectin receptor expressed on a subset of dendritic cells. CLEC9A binds exposed actin filaments on dead cells and has been associated with cross-presentation of antigens.

CLEC9A is a target for directing antigens to dendritic cells in vaccine and immunotherapy approaches under study. Clec9a-deficient mice show altered cross-presentation of cell-associated antigens.

Model Applications

Humanized CLEC9A models, in which the human receptor replaces the mouse counterpart, have been used to evaluate CLEC9A-targeted vaccine and immunotherapy approaches in defined experimental settings.

Custom CLEC9A Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials. npj Vaccines. 2025. doi:10.1038/s41541-025-01084-2
• Sancho D et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009. doi:10.1038/nature07750

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Xcr1 · Batf3 · Clec4c · Cd8a