CSF1 Mouse Models

Why Model CSF1

Csf1 is the mouse ortholog of human CSF1 and encodes macrophage colony-stimulating factor (M-CSF), a cytokine that signals through the receptor CSF1R. CSF1 has been associated with the differentiation, survival, and function of macrophages and related myeloid cells.

The CSF1/CSF1R axis has been associated with tumor-associated macrophages, tenosynovial giant cell tumor, and fibrotic and inflammatory conditions, and CSF1-pathway-directed agents are used or under study. Csf1-deficient mice (op/op) show reduced macrophages and osteopetrosis.

Model Applications

Humanized CSF1 models, in which the human cytokine replaces the mouse counterpart, have been used to support human myeloid-cell functions and to evaluate CSF1-pathway-directed agents in defined experimental settings.

Custom CSF1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Efficacy and safety of CSF1R inhibitors for recurrent or unresectable tenosynovial giant cell tumor: a systematic review and meta-analysis of phase III randomized controlled trials. Asia Pac J Clin Oncol. 2026. doi:10.1111/ajco.70211
• Kawasaki ES et al. Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). Science. 1985. doi:10.1126/science.2996129

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Csf1r · Csf2 · Il34 · Spi1