CX3CL1 Mouse Models

Why Model CX3CL1

Cx3cl1 is the mouse ortholog of human CX3CL1 and encodes fractalkine, a chemokine that exists in membrane-bound and soluble forms and signals through the receptor CX3CR1. CX3CL1 has been associated with adhesion and recruitment of monocytes and with neuron-microglia communication.

CX3CL1-CX3CR1 signaling has been associated with neuroinflammatory, inflammatory, and other conditions, and CX3CL1-pathway-directed approaches are under study. Cx3cl1-deficient mice show altered monocyte and microglial responses.

Model Applications

Humanized CX3CL1 models, in which the human chemokine replaces the mouse counterpart, have been used to evaluate CX3CL1-pathway-directed agents in defined experimental settings.

Custom CX3CL1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The complex role of the chemokine CX3CL1/fractalkine in major depressive disorder: a narrative review of preclinical and clinical studies. Brain Behav Immun Health. 2024. doi:10.1016/j.bbih.2024.100778
• Bazan JF et al. A new class of membrane-bound chemokine with a CX3C motif. Nature. 1997. doi:10.1038/385640a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cx3cr1 · Ccl2 · Cxcl12 · Itgb1