CXCR3 Mouse Models

Why Model CXCR3

Cxcr3 is the mouse ortholog of human CXCR3 and encodes CXCR3 (CD183), a class A G-protein-coupled chemokine receptor that binds the chemokines CXCL9, CXCL10, and CXCL11. CXCR3 has been associated with recruitment of activated T cells and other cells to inflamed tissues.

CXCR3 has been associated with inflammatory, autoimmune, and antitumor immune responses, and CXCR3-pathway-directed approaches are under study. Cxcr3-deficient mice show altered T-cell trafficking.

Model Applications

Humanized CXCR3 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate CXCR3-directed agents in defined experimental settings.

Custom CXCR3 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology. Cytokine Growth Factor Rev. 2025. doi:10.1016/j.cytogfr.2025.05.003
• Loetscher M et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996. doi:10.1084/jem.184.3.963

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cxcl9 · Cxcl10 · Cxcl11 · Ccr5