DSG2 Mouse Models

Why Model DSG2

Dsg2 is the mouse ortholog of human DSG2 and encodes desmoglein-2, a desmosomal cadherin that mediates cell-cell adhesion in epithelia and cardiac muscle. Desmoglein-2 has been associated with maintenance of tissue integrity.

DSG2 mutations are associated with arrhythmogenic cardiomyopathy, and desmoglein-2 has roles in epithelial cancers; it also serves as a receptor for certain adenoviruses. Dsg2 mutant mice develop cardiac phenotypes resembling the human disease.

Model Applications

Humanized DSG2 models, including those carrying disease-associated alleles, have been used to study desmoglein-2 biology and cardiac disease in defined experimental settings.

Custom DSG2 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Endurance training and preload reduction in heterozygous DSG2 mutant mice with an arrhythmogenic cardiomyopathy-like phenotype. Biomedicines. 2024. doi:10.3390/biomedicines12050985
• Pilichou K et al. Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation. 2006. doi:10.1161/circulationaha.105.583674

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Dsp · Pkp2 · Dsg1 · Jup