GHRL Mouse Models

Why Model GHRL

Ghrl is the mouse ortholog of human GHRL and encodes preproghrelin, which is processed into the acylated peptide hormone ghrelin (and obestatin). Ghrelin acts on the growth-hormone-secretagogue receptor and has been associated with stimulation of appetite and release of growth hormone.

Ghrelin has been associated with regulation of food intake and energy balance, and the ghrelin system is studied as a target for metabolic and appetite-related conditions. Ghrl-deficient mice are viable with modest metabolic phenotypes.

Model Applications

Humanized GHRL models, in which the human gene replaces the mouse counterpart, have been used to study ghrelin biology and to evaluate ghrelin-system-directed agents in defined experimental settings.

Custom GHRL Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Effect of long-term exercise on circulating ghrelin in overweight and obese individuals: a systematic review and meta-analysis. Front Nutr. 2025. doi:10.3389/fnut.2025.1518143
• Kojima M et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999. doi:10.1038/45230

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ghsr · Mboat4 · Lep · Gh