Gpc3 Mouse Models

Why Model Gpc3

Gpc3 is the mouse ortholog of human GPC3 and encodes glypican-3, a GPI-anchored heparan sulfate proteoglycan. Glypican-3 has been associated with regulation of cell growth and signaling during development, and loss-of-function variants are linked to an overgrowth syndrome.

Glypican-3 is expressed on most hepatocellular carcinomas with limited expression in normal adult liver, and glypican-3-directed agents, including CAR T cells and antibodies, have been evaluated; clinical results have varied. Gpc3-deficient mice show developmental overgrowth features.

Model Applications

Humanized GPC3 models, in which the human protein replaces the mouse counterpart, have been used to evaluate glypican-3-targeted therapeutics in defined experimental settings.

Custom Gpc3 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Combination therapy strategies targeting glypican-3 in hepatocellular carcinoma: a comprehensive review. Cytokine Growth Factor Rev. 2025. doi:10.1016/j.cytogfr.2025.12.006
• Capurro M et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003. doi:10.1016/s0016-5085(03)00689-9

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Gpc1 · Igf2 · Sulf2 · Afp