GPNMB Mouse Models

Why Model GPNMB

Gpnmb is the mouse ortholog of human GPNMB and encodes glycoprotein NMB (osteoactivin, DC-HIL), a transmembrane glycoprotein expressed on several cell types including macrophages and melanocytes. GPNMB has been associated with roles in tissue repair and modulation of immune responses.

GPNMB is overexpressed on melanoma and other tumors and has been studied as an antibody–drug-conjugate target; it has also been associated with Parkinson’s disease risk. Gpnmb-deficient mice show altered tissue responses in some models.

Model Applications

Humanized GPNMB models, in which the human protein replaces the mouse counterpart, have been used to evaluate GPNMB-directed agents in defined experimental settings.

Custom GPNMB Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma. Acta Neuropathol Commun. 2024. doi:10.1186/s40478-024-01754-7
• Weterman MA et al. nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. Int J Cancer. 1995. doi:10.1002/ijc.2910600111

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Mitf · Pmel · Cd63 · Sdc4