HBA1 Mouse Models

Why Model HBA1

HBA1 encodes an alpha-globin subunit of adult hemoglobin; in mice the orthologous alpha-globin genes include Hba-a1 and Hba-a2. Alpha-globin combines with beta-globin and heme to form hemoglobin, which has been associated with oxygen transport in red blood cells.

Deletions and mutations affecting the alpha-globin genes cause alpha-thalassemia, and the alpha-globin locus is studied in hematology and gene-therapy research. Mouse models carrying human alpha-globin alleles have been developed to study these conditions.

Model Applications

Humanized HBA1 models, including those carrying human alpha-globin alleles, have been used to study alpha-globin disorders in defined experimental settings.

Custom HBA1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Systematic review and evidence gap assessment of the clinical, quality of life, and economic burden of alpha-thalassemia. eJHaem. 2024. doi:10.1002/jha2.882
• Liebhaber SA et al. Cloning and complete nucleotide sequence of human 5’-alpha-globin gene. Proc Natl Acad Sci U S A. 1980. doi:10.1073/pnas.77.12.7054

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Hbb-bs · Hba-a2 · Alas2 · Slc4a1