IFNAR1 Mouse Models

Why Model IFNAR1

Ifnar1 is the mouse ortholog of human IFNAR1 and encodes a subunit of the type I interferon receptor, which together with IFNAR2 binds type I interferons. IFNAR1 signaling, through the JAK-STAT pathway, has been associated with antiviral and immunomodulatory responses.

Excess type I interferon signaling is implicated in systemic lupus erythematosus and related conditions, and an antibody blocking IFNAR1 is approved for lupus. Ifnar1-deficient mice are viable and show impaired antiviral responses.

Model Applications

Humanized IFNAR1 models, in which the human subunit replaces the mouse counterpart, have been used to evaluate IFNAR1-directed agents in defined experimental settings.

Custom IFNAR1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Rationale for investigating the use of anifrolumab in neuropsychiatric systemic lupus erythematosus: a combined narrative and case-based systematic literature review. Front Immunol. 2026. doi:10.3389/fimmu.2026.1750071
• Uzé G et al. Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell. 1990. doi:10.1016/0092-8674(90)90738-z

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ifnar2 · Ifnb1 · Jak1 · Stat1