Il15 Mouse Models

Why Model Il15

Il15 is the mouse ortholog of human IL15 and encodes interleukin-15, a cytokine that shares receptor components with IL-2 and is often presented in trans by IL-15 receptor alpha. IL-15 has been associated with the development and maintenance of natural killer cells and memory CD8 T cells.

IL-15-based agents, including IL-15 superagonists, are under study in cancer immunotherapy. Il15-deficient mice are viable and show reduced natural killer and memory T-cell populations.

Model Applications

Humanized IL15 models, often paired with IL-15 receptor components, have been used to evaluate IL-15-based agents and to support human immune-cell functions in defined experimental settings.

Il15 knockout mice have been used to study natural killer and memory T-cell biology.

Custom Il15 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Interleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis. Front Immunol. 2024. doi:10.3389/fimmu.2023.1288537
• Grabstein KH et al. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science. 1994. doi:10.1126/science.8178155

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il15ra · Il2rb · Il2rg · Ncr1