IL7R Mouse Models

Why Model IL7R

Il7r is the mouse ortholog of human IL7R and encodes the interleukin-7 receptor alpha chain (CD127), which pairs with the common gamma chain. IL-7 receptor signaling has been associated with development and homeostasis of T cells and other lymphocytes.

IL7R alterations are associated with severe combined immunodeficiency and with T-cell acute lymphoblastic leukemia, and IL-7-pathway-directed approaches are under study. Il7r-deficient mice show impaired lymphocyte development.

Model Applications

Humanized IL7R models, in which the human chain replaces the mouse counterpart, have been used to study IL-7-dependent lymphocyte biology and to evaluate IL-7-pathway-directed agents in defined experimental settings.

Custom IL7R Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Potential of interleukin-7 in sepsis as a biomarker and therapeutic agent: a narrative review. Front Med (Lausanne). 2025. doi:10.3389/fmed.2025.1649049
• Goodwin RG et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990. doi:10.1016/0092-8674(90)90342-c

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il7 · Il2rg · Jak3 · Tslp