LGR5 Mouse Models

Why Model LGR5

Lgr5 is the mouse ortholog of human LGR5 and encodes a leucine-rich-repeat G-protein-coupled receptor that binds R-spondins and potentiates Wnt signaling. LGR5 marks stem cells in the intestine and other tissues and has been associated with tissue renewal.

LGR5 has been associated with cancer-stem-cell populations and treatment resistance in colorectal and other cancers, and LGR5-directed approaches are under study. Lgr5 reporter and lineage-tracing mice are widely used in stem-cell research.

Model Applications

Humanized LGR5 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate LGR5-directed agents in defined experimental settings.

Lgr5 reporter mice are used to track and study stem cells.

Custom LGR5 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• LGR5: an emerging therapeutic target for cancer metastasis and chemotherapy resistance. Cancer Metastasis Rev. 2025. doi:10.1007/s10555-024-10239-x
• Barker N et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007. doi:10.1038/nature06196

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Rspo1 · Lgr4 · Lgr6 · Wnt3