LILRB4 Mouse Models

Why Model LILRB4

LILRB4 (ILT3, CD85k) encodes an immunoglobulin-superfamily inhibitory receptor expressed on myeloid and other cells; the mouse genome contains related paralogs, including Lilrb4b. LILRB4 has been associated with inhibitory signaling and modulation of myeloid-cell and T-cell responses.

LILRB4 is expressed on monocytic acute myeloid leukemia and on myeloid-derived suppressor cells, and LILRB4-directed agents are under study in cancer. Mouse models have been used to study LILRB4-pathway biology.

Model Applications

Humanized LILRB4 models, in which the human receptor is expressed in mice, have been used to evaluate LILRB4-directed antibodies and related agents in defined experimental settings.

Custom LILRB4 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors. Cell Rep Med. 2024. doi:10.1016/j.xcrm.2023.101374
• Cella M et al. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 1997. doi:10.1084/jem.185.10.1743

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Lilrb2 · Lair1 · Pirb · Fcgr2b