MPL Mouse Models

Why Model MPL

Mpl is the mouse ortholog of human MPL and encodes the thrombopoietin receptor (CD110, TPOR), a type I cytokine receptor on megakaryocytes and hematopoietic progenitors. MPL binds thrombopoietin and has been associated with platelet production and hematopoietic stem-cell maintenance.

MPL mutations are associated with myeloproliferative neoplasms and inherited thrombocytopenias, and thrombopoietin-receptor agonists are used for immune thrombocytopenia and other conditions. Mpl-deficient mice show reduced platelets and megakaryocytes.

Model Applications

Humanized MPL models, in which the human receptor replaces the mouse counterpart, have been used to evaluate thrombopoietin-receptor-directed agents in defined experimental settings.

Custom MPL Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Thrombopoietin receptor agonists and thrombotic events in immune thrombocytopenia: a systematic review and meta-analysis of randomized controlled trials. Biomed Rep. 2024. doi:10.3892/br.2024.1732
• Vigon I et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci U S A. 1992. doi:10.1073/pnas.89.12.5640

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Thpo · Jak2 · Gata1 · Calr