NGF Mouse Models

Why Model NGF

Ngf is the mouse ortholog of human NGF and encodes nerve growth factor, a neurotrophin that binds the receptors TrkA and p75. NGF has been associated with the development and maintenance of certain sensory and sympathetic neurons and with pain signaling.

NGF has been associated with chronic pain, and anti-NGF antibodies have been evaluated for musculoskeletal pain; NGF mutations cause a hereditary sensory and autonomic neuropathy. Ngf-deficient mice show loss of certain sensory and sympathetic neurons.

Model Applications

Humanized NGF models, in which the human protein replaces the mouse counterpart, have been used to evaluate NGF-directed agents in defined experimental settings.

Custom NGF Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Efficacy and safety of anti-nerve growth factor monoclonal antibodies in managing chronic musculoskeletal pain: a systematic review with network meta-analysis. Drugs. 2026. doi:10.1007/s40265-026-02304-2
• Ullrich A et al. Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 1983. doi:10.1038/303821a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ntrk1 · Ngfr · Bdnf · Ntf3