OSM Mouse Models

Why Model OSM

Osm is the mouse ortholog of human OSM and encodes oncostatin M, an IL-6-family cytokine produced by several immune and other cells. OSM signals through receptor complexes containing gp130 and has been associated with regulation of inflammation, tissue remodeling, and hematopoiesis.

OSM has been associated with inflammatory bowel disease and fibrotic conditions, and OSM-pathway-directed approaches are under study. Osm-deficient and receptor-deficient mice show altered inflammatory responses.

Model Applications

Humanized OSM models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate OSM-pathway-directed agents in defined experimental settings.

Custom OSM Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Role of oncostatin M in the prognosis of inflammatory bowel disease: a meta-analysis. World J Gastrointest Surg. 2024. doi:10.4240/wjgs.v16.i1.228
• Zarling JM et al. Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci U S A. 1986. doi:10.1073/pnas.83.24.9739

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Osmr · Lifr · Il6st · Lif