Tnfrsf17 Mouse Models

Why Model Tnfrsf17

Tnfrsf17 is the mouse ortholog of human TNFRSF17 and encodes BCMA (B-cell maturation antigen, CD269), a TNF-receptor-superfamily member expressed mainly on plasma cells and late-stage B cells. BCMA binds the ligands BAFF and APRIL and has been associated with plasma-cell survival and antibody responses.

BCMA is expressed on malignant plasma cells in multiple myeloma, and BCMA-directed CAR T cells and bispecific antibodies are used in relapsed or refractory disease; responses vary and relapse can occur. Tnfrsf17-deficient mice are viable with reduced numbers of long-lived plasma cells.

Model Applications

Humanized TNFRSF17 (BCMA) models, in which the human protein replaces the mouse counterpart, have been used to evaluate BCMA-directed CAR T cells and bispecific antibodies in immunocompetent mice, including in combination settings.

Tnfrsf17 models have been used to study plasma-cell biology in defined experimental settings.

Custom Tnfrsf17 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Comparative efficacy and safety of BCMA-targeted CAR T cells and bispecific antibodies in relapsed/refractory multiple myeloma: a meta-analysis. Ann Hematol. 2025. doi:10.1007/s00277-025-06524-6
• Munshi NC et al. Idecabtagene vicleucel in relapsed and refractory multiple myeloma. N Engl J Med. 2021. doi:10.1056/NEJMoa2024850

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Tnfsf13b · Tnfsf13 · Tnfrsf13b · Tnfrsf13c