Overview
Cytokine and receptor humanization refers to the genetic replacement of mouse cytokines, receptors, or ligand–receptor pairs with their human equivalents. These models recreate critical components of the human immune network for accurate evaluation of human biologics.
Frequently Asked Questions
Why are cytokine humanizations important?
Human cytokines often fail to interact efficiently with murine receptors due to species-specific signaling differences. Humanization enables functional human immune cell engraftment and signaling.
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