Btk Conditional Knockout, Knockin, Knockout mouse models

Available Btk catalog models

3 Btk lines with QC documentation and technical support. Btk floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Btk-Flox

  CKO

  CKO

  These strains carry loxP sites flanking exon 4-5 of Btk gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Btk gene.

  Sperm CryopreservedCKO 240595
  Order

• Btk-C481S

  KI

  Point Mutation

  These mice carry a C481S mutation of Btk gene.

  Sperm CryopreservedKI 225099
  Order

• Btk-KO

  KO

  KO, Disease Model

  This Btk knockout mouse model was generated by deleting the Exon 4-5 region of the Btk .

  Sperm CryopreservedKO 190005
  Order

About Btk Mouse Model Types

A Btk knockout mouse has the Btk gene permanently inactivated, enabling loss of function studies. A Btk conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Btk, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Btk knockin models carry a precisely inserted sequence at the Btk locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Btk organized by modification type. Each URL is indexable and matches common search patterns.

Breed this line with ingenious targeting laboratory

Send the Btk line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.