Dot1l Conditional Knockout, Knockout mouse models

Available Dot1l catalog models

3 Dot1l lines with QC documentation and technical support. Dot1l floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Dot1l-Flox

  CKO

  CKO, Disease Model

  These mice carry loxP sites flanking exon 2 of Dot1l gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Dot1l gene.

  In production — inquireCKO 253748
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• Dot1l-KO(2)

  KO

  KO

  Exon 2 of Dot1l gene was deleted to generate Dot1l knockout mice.

  In DevelopmentKO 225080
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• Dot1l-KO

  KO

  KO

  Exon 5 of Dot1l gene was deleted to generate Dot1l knockout mice

  Embryo CryopreservedKO 210204
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About Dot1l Mouse Model Types

A Dot1l knockout mouse has the Dot1l gene permanently inactivated, enabling loss of function studies. A Dot1l conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Dot1l, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.

Modifications available

Jump to catalog backed pages for Dot1l organized by modification type. Each URL is indexable and matches common search patterns.

Breed this line with ingenious targeting laboratory

Send the Dot1l line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.