KPC Knockin mouse model

Available KPC catalog models

1 KPC line with QC documentation and technical support.

• KPC

  KI

  CKO, Point Mutation, Cre/Dre Toolbox, Disease Model

  The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

  LiveKI 210096
  Order

About KPC Mouse Model Types

KPC knockin models carry a precisely inserted sequence at the KPC locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for KPC organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the KPC line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.