MHCII/B2m Immunodeficient, Knockin, Xenograft-Applicable mouse models

Available MHCII/B2m catalog models

3 MHCII/B2m lines with QC documentation and technical support.

• MHCII/B2m-KO(M-NSG)

  NSG

  KO, Immunodeficient

  All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

  LiveNSG 014
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• MHCII/B2m-KO-Fcgrt-B2m-Linker-Fcgrt(M-NSG)

  KI

  Other

  On the existing MHCII/B2m-KO(NMG) NSG 014 strain, the B2m-Linker-Fcgrt was inserted into the mouse Fcgrt gene.

  In DevelopmentKI 263637
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• MHCII/B2m-KO(M-NSG)/hIL2-Tg(M-NSG)

  XA

  KO, Target-Humanized, Immunodeficient, Random Transgenic

  The hIL2-Tg(NMG)(NMG 010) was crossed with MHCII/B2m-KO(NMG)(NMG 014) to generate MHCII/B2m-KO/hIL2-Tg(NMG) mice.

  LiveXA 250087
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About MHCII/B2m Mouse Model Types

MHCII/B2m knockin models carry a precisely inserted sequence at the MHCII/B2m locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for MHCII/B2m organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

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