Mc4r Conditional Knockout, Knockin, Knockout mouse models

Available Mc4r catalog models

4 Mc4r lines with QC documentation and technical support. Mc4r floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Mc4r-Flox

  CKO

  CKO, Disease Model

  These mice carry loxP sites flanking exon 1 of Mc4r gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Mc4r gene.

  Sperm CryopreservedCKO 200195
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• Mc4r-2A-Cre

  KI

  Cre/Dre Toolbox

  A T2A-Cre expression cassette was knocked into the Mc4r gene stop codon site.

  Sperm CryopreservedKI 200220
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• Mc4r-KO

  KO

  KO, Disease Model

  Exon 1 of Mc4r gene was deleted to generate Mc4r knockout mice.

  Sperm CryopreservedKO 200357
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• Mc4r-KO(2)

  KO

  KO, Disease Model

  exon 1 of Mc4r gene was deleted to generate Mc4r knockout mice via CRISPR/Cas9 mediated recombination.

  F0 Embryo CryopreservedKO 205021
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About Mc4r Mouse Model Types

A Mc4r knockout mouse has the Mc4r gene permanently inactivated, enabling loss of function studies. A Mc4r conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mc4r, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Mc4r knockin models carry a precisely inserted sequence at the Mc4r locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Mc4r organized by modification type. Each URL is indexable and matches common search patterns.

Breed this line with ingenious targeting laboratory

Send the Mc4r line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.