Npc1 Conditional Knockout, Knockin, Knockout mouse models

Available Npc1 catalog models

3 Npc1 lines with QC documentation and technical support. Npc1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Npc1-Flox

  CKO

  CKO, Disease Model

  These mice carry loxP sites flanking exon 9 of Npc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Npc1 gene.

  Sperm CryopreservedCKO 200070
  Order

• Npc1-I1060T

  KI

  Point Mutation

  The I1060T point mutation is located in exon21 of mouse Npc1 gene. This Npc1 point mutation mouse model was established by introduce a T>C transversion at the 138th nucleotide of exon21.

  Sperm CryopreservedKI 18059
  Order

• Npc1-KO

  KO

  KO

  Exon 9 of Npc1 gene was deleted to generate Npc1 knockout mice.

  Sperm CryopreservedKO 205053
  Order

About Npc1 Mouse Model Types

A Npc1 knockout mouse has the Npc1 gene permanently inactivated, enabling loss of function studies. A Npc1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Npc1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Npc1 knockin models carry a precisely inserted sequence at the Npc1 locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Npc1 organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the Npc1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.