Oprk1 Conditional Knockout, Knockin, Knockout mouse models

Available Oprk1 catalog models

3 Oprk1 lines with QC documentation and technical support. Oprk1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Oprk1-Flox

  CKO

  CKO

  These mice carry loxP sites flanking exon 3 of Oprk1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Oprk1 gene.

  Sperm CryopreservedCKO 200120
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• Oprk1-2A-Cre

  KI

  Cre/Dre Toolbox

  2A-Cre expression cassette was knocked into the Oprk1 gene stop codon site. Oprk1 (opioid receptor, kappa 1) encodes opioid receptor which was expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.

  LiveKI 200299
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• Oprk1-KO

  KO

  KO

  Exon 3 of Oprk1 gene was deleted to generate Oprk1 knockout mice.

  F0 Embryo CryopreservedKO 190642
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About Oprk1 Mouse Model Types

A Oprk1 knockout mouse has the Oprk1 gene permanently inactivated, enabling loss of function studies. A Oprk1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Oprk1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Oprk1 knockin models carry a precisely inserted sequence at the Oprk1 locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Oprk1 organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

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Send the Oprk1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.