Ttr Conditional Knockout, Knockin, Knockout mouse models

Available Ttr catalog models

5 Ttr lines with QC documentation and technical support. Ttr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Ttr-Flox

  CKO

  CKO

  These mice carry loxP sites flanking exon 2 of Ttr gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ttr gene.

  Sperm CryopreservedCKO 226502
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• Ttr-2A-EGFP-2A-CreERT2

  KI

  Cre/Dre Toolbox, Fluorescent Model

  The P2A-EGFP-T2A-CreERT2 expression cassette was knocked into the Ttr gene stop codon site.

  Sperm CryopreservedKI 252249
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• Ttr-sGFP

  KI

  Fluorescent Model

  A sGFP-wpre-polyA expression cassette was knocked into the Ttr gene start codon site.

  Embryo CryopreservedKI 200203
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• Ttr-G103R

  KI

  Point Mutation

  These mice carry a p.G103R mutation of Ttr gene.

  Embryo CryopreservedKI 00134
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• Ttr-KO

  KO

  KO

  Exon 2 of Ttr gene was deleted to generate Ttr knockout mice.

  Sperm CryopreservedKO 200555
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About Ttr Mouse Model Types

A Ttr knockout mouse has the Ttr gene permanently inactivated, enabling loss of function studies. A Ttr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ttr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Ttr knockin models carry a precisely inserted sequence at the Ttr locus, useful for reporter, tag, or humanization studies.

Modifications available

Jump to catalog backed pages for Ttr organized by modification type. Each URL is indexable and matches common search patterns.

Breed this line with ingenious targeting laboratory

Send the Ttr line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.