Wrn Conditional Knockout, Knockout mouse models

Available Wrn catalog models

3 Wrn lines with QC documentation and technical support. Wrn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

• Wrn-Flox

  CKO

  CKO

  These mice carry loxP sites flanking exon 9-10 of Wrn gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Wrn gene.

  LiveCKO 253589
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• Wrn-KO(2)

  KO

  KO

  The exon 9-10 of Wrn gene was deleted to generate Wrn knockout mouse.

  LiveKO 260284
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• Wrn-KO

  KO

  KO

  Exon 5-8 of Wrn gene was deleted to generate Wrn knockout mice.

  In production — inquireKO 190902
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About Wrn Mouse Model Types

A Wrn knockout mouse has the Wrn gene permanently inactivated, enabling loss of function studies. A Wrn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Wrn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.

Modifications available

Jump to catalog backed pages for Wrn organized by modification type. Each URL is indexable and matches common search patterns.

Related Gene Targets

Breed this line with ingenious targeting laboratory

Send the Wrn line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.