Angptl3 Mouse Models

Why Model Angptl3

Angptl3 is the mouse ortholog of human ANGPTL3 and encodes angiopoietin-like 3, a secreted protein produced mainly by the liver. ANGPTL3 has been associated with inhibition of lipoprotein lipase and endothelial lipase and with regulation of plasma lipids.

Loss-of-function ANGPTL3 variants are associated with low plasma lipids, and ANGPTL3-directed agents are used or under study for lipid lowering. Angptl3-deficient mice show reduced plasma triglycerides and cholesterol.

Model Applications

Humanized ANGPTL3 models, in which the human protein replaces the mouse counterpart, have been used to evaluate ANGPTL3-targeted agents, including antibodies and nucleic-acid-based approaches, in defined experimental settings.

Custom Angptl3 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Lipid, lipoprotein, and biomarker changes with ANGPTL3 inhibition: a meta-analysis of controlled randomized trials. Atherosclerosis. 2026. doi:10.1016/j.atherosclerosis.2026.121167
• Koishi R et al. Angptl3 regulates lipid metabolism in mice. Nat Genet. 2002. doi:10.1038/ng814

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Angptl4 · Lpl · Apoc3 · Angptl8