BSG Mouse Models

Why Model BSG

Bsg is the mouse ortholog of human BSG and encodes basigin (CD147, EMMPRIN), an immunoglobulin-superfamily transmembrane glycoprotein. Basigin has been associated with induction of matrix metalloproteinases and with transport functions, and it interacts with several partner proteins.

CD147 is overexpressed on many tumors and has been associated with invasion and with roles in other conditions, and CD147-directed approaches are under study. Bsg-deficient mice show defects in reproduction and sensory function.

Model Applications

Humanized BSG (CD147) models, in which the human protein replaces the mouse counterpart, have been used to evaluate CD147-directed agents in defined experimental settings.

Custom BSG Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• CD147 expression as a clinicopathological and prognostic indicator in breast cancer: a meta-analysis and bioinformatics analysis. BMC Cancer. 2024. doi:10.1186/s12885-024-13202-9
• Igakura T et al. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev Biol. 1998. doi:10.1006/dbio.1997.8819

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Slc16a1 · Mmp2 · Cav1 · Slc7a11