CCR6 Mouse Models

Why Model CCR6

Ccr6 is the mouse ortholog of human CCR6 and encodes CCR6 (CD196), a class A G-protein-coupled chemokine receptor that binds CCL20. CCR6 is expressed on Th17 cells, regulatory T cells, and other leukocytes and has been associated with their recruitment to mucosal and inflamed tissues.

CCR6 has been associated with psoriasis, inflammatory bowel disease, and tumor immunity, and CCR6-pathway-directed approaches are under study. Ccr6-deficient mice show altered mucosal immune responses.

Model Applications

Humanized CCR6 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate CCR6-directed agents in defined experimental settings.

Custom CCR6 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis. Neoplasia. 2024. doi:10.1016/j.neo.2024.101103
• Baba M et al. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997. doi:10.1074/jbc.272.23.14893

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Ccl20 · Rorc · Il17a · Ccr7