Il17a Mouse Models

Why Model Il17a

Il17a is the mouse ortholog of human IL17A and encodes interleukin-17A, a cytokine produced mainly by Th17 cells and other innate and adaptive immune cells. IL-17A signals through IL-17 receptor complexes and has been associated with recruitment of neutrophils and promotion of inflammatory responses at barrier tissues.

IL-17A is implicated in psoriasis, psoriatic arthritis, and other inflammatory diseases, and IL-17A-directed antibodies are in clinical use. Il17a-deficient mice are viable and show reduced inflammation in several disease models and altered host defense.

Model Applications

Humanized IL17A models, in which the human cytokine replaces the mouse counterpart, have been used to evaluate IL-17A-targeted antibodies in immunocompetent mice.

Il17a knockout mice have been used to study IL-17-dependent inflammation.

Custom Il17a Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Efficacy and safety of IL-17, IL-12/23, and IL-23 inhibitors for psoriatic arthritis: a network meta-analysis of randomized controlled trials. Front Immunol. 2025. doi:10.3389/fimmu.2025.1654343
• Yao Z et al. Human IL-17: a novel cytokine derived from T cells. J Immunol. 1995. doi:10.4049/jimmunol.155.12.5483

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Il17f · Il17ra · Il23a · Rorc