CLEC12A Mouse Models

Why Model CLEC12A

Clec12a is the mouse ortholog of human CLEC12A and encodes CLEC12A (CLL-1, MICL), a C-type lectin-like inhibitory receptor expressed on myeloid cells. CLEC12A has been associated with regulation of myeloid-cell activation and inflammation.

CLEC12A is expressed on acute myeloid leukemia cells, including on leukemic-stem-cell-enriched populations, and CLEC12A-directed agents, including bispecific antibodies and CAR approaches, have been evaluated. Clec12a-deficient mice are viable with altered myeloid inflammatory responses.

Model Applications

Humanized CLEC12A models, in which the human protein replaces the mouse counterpart, have been used to evaluate CLEC12A-directed agents in defined experimental settings.

Custom CLEC12A Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• CLEC12A-directed immunocytokine with target cell-restricted IL-15 activity for treatment of acute myeloid leukemia. Front Immunol. 2025. doi:10.3389/fimmu.2025.1561823
• Marshall ASJ et al. Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL). J Biol Chem. 2004. doi:10.1074/jbc.m313127200

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Clec12b · Clec7a · Clec9a · Trem2