CXCR5 Mouse Models

Why Model CXCR5

Cxcr5 is the mouse ortholog of human CXCR5 and encodes CXCR5 (CD185), a class A G-protein-coupled chemokine receptor that binds CXCL13. CXCR5 has been associated with homing of B cells and follicular helper T cells to lymphoid follicles.

CXCR5 has been associated with germinal-center responses, autoimmune conditions, and certain lymphomas, and CXCR5-directed approaches are under study, including in cell therapies. Cxcr5-deficient mice show disrupted lymphoid architecture.

Model Applications

Humanized CXCR5 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate CXCR5-directed agents in defined experimental settings.

Custom CXCR5 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases. Cell Mol Biol Lett. 2024. doi:10.1186/s11658-024-00653-y
• Förster R et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996. doi:10.1016/s0092-8674(00)81798-5

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Cxcl13 · Bcl6 · Cxcr4 · Ccr7