DKK1 Mouse Models

Why Model DKK1

Dkk1 is the mouse ortholog of human DKK1 and encodes Dickkopf-1, a secreted antagonist of the Wnt/β-catenin pathway. DKK1 has been associated with regulation of Wnt signaling in development and bone.

DKK1 has been associated with bone loss in multiple myeloma and with roles in several cancers and immune regulation, and DKK1-directed agents are under study. Dkk1-deficient and mutant mice show skeletal and developmental phenotypes.

Model Applications

Humanized DKK1 models, in which the human protein replaces the mouse counterpart, have been used to evaluate DKK1-directed agents in defined experimental settings.

Custom DKK1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer. Nat Commun. 2025. doi:10.1038/s41467-025-56420-w
• Glinka A et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998. doi:10.1038/34848

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Wnt3a · Lrp6 · Kremen1 · Ctnnb1