EPCAM Mouse Models

Why Model EPCAM

Epcam is the mouse ortholog of human EPCAM and encodes the epithelial cell adhesion molecule (CD326), a transmembrane glycoprotein expressed on many epithelia. EpCAM has been associated with cell-cell adhesion and with signaling that influences proliferation.

EpCAM is overexpressed on many carcinomas and is used as a tumor marker and therapeutic target, and EPCAM mutations cause congenital tufting enteropathy. Epcam-deficient mice show intestinal defects and early lethality.

Model Applications

Humanized EPCAM models, in which the human protein replaces the mouse counterpart, have been used to evaluate EpCAM-directed therapeutics, including bispecific antibodies and cell therapies, in defined experimental settings.

Custom EPCAM Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Innovative approaches in the therapeutic application of EpCAM aptamer for targeted cancer treatment: a review. Biochim Biophys Acta Gen Subj. 2026. doi:10.1016/j.bbagen.2026.130982
• Litvinov SV et al. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol. 1994. doi:10.1083/jcb.125.2.437

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

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