Erbb2 Mouse Models

Why Model Erbb2

Erbb2 is the mouse ortholog of human ERBB2 and encodes HER2 (ErbB2), a receptor tyrosine kinase of the ErbB/EGFR family. HER2 has no known direct ligand and signals through heterodimerization with other ErbB receptors, and has been associated with activation of downstream pathways including RAS–MAPK and PI3K–AKT.

ERBB2 amplification or overexpression has been associated with a subset of breast and gastric cancers, and HER2-directed antibodies, antibody–drug conjugates, and kinase inhibitors are used in HER2-positive disease; responses vary by tumor type and prior therapy. Mouse models expressing human ERBB2 have been used to study HER2 biology and HER2-targeted agents.

Model Applications

Humanized ERBB2 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate HER2-directed antibodies and antibody–drug conjugates in immunocompetent mice.

Transgenic and knock-in Erbb2 models have been used to study HER2-driven tumorigenesis in defined experimental settings.

Custom Erbb2 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Management of patients with advanced-stage HER2-positive breast cancer: current evidence and future perspectives. Nat Rev Clin Oncol. 2024. doi:10.1038/s41571-023-00849-9
• Slamon DJ et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987. doi:10.1126/science.3798106

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Egfr · Erbb3 · Erbb4 · Grb7