Egfr Mouse Models

Why Model Egfr

Egfr is the mouse ortholog of human EGFR and encodes the epidermal growth factor receptor (HER1/ErbB1), a receptor tyrosine kinase activated by ligands including EGF and TGF-α. Ligand binding promotes receptor dimerization and signaling through pathways including RAS–MAPK and PI3K–AKT, which have been associated with cell proliferation and survival.

Activating EGFR mutations and overexpression have been associated with non-small cell lung cancer and other tumors, and EGFR tyrosine kinase inhibitors and antibodies are used in selected EGFR-driven cancers; resistance commonly emerges. Homozygous Egfr-null mice show strain-dependent lethality and epithelial defects.

Model Applications

Humanized EGFR models, in which the human receptor replaces the mouse counterpart, have been used to evaluate EGFR-targeted antibodies and inhibitors.

Conditional and mutant Egfr models have been used to study EGFR signaling and EGFR-driven disease in defined experimental settings.

Custom Egfr Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• The changing treatment landscape of EGFR-mutant non-small-cell lung cancer. Nat Rev Clin Oncol. 2024. doi:10.1038/s41571-024-00971-2
• Ullrich A et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 1984. doi:10.1038/309418a0

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Erbb2 · Erbb3 · Kras · Egf