F11 Mouse Models

Why Model F11

F11 is the mouse ortholog of human F11 and encodes coagulation factor XI, a serine protease zymogen of the intrinsic coagulation pathway. Activated factor XI has been associated with amplification of thrombin generation.

Factor XI has been associated with thrombosis while having a comparatively limited role in normal hemostasis, and factor XI inhibitors are under study as anticoagulants intended to reduce bleeding risk. F11-deficient mice are viable with prolonged clotting times and reduced experimental thrombosis.

Model Applications

Humanized F11 models, in which the human protein replaces the mouse counterpart, have been used to evaluate factor XI-directed anticoagulants in defined experimental settings.

Custom F11 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism. Nat Rev Cardiol. 2025. doi:10.1038/s41569-025-01144-z
• Fujikawa K et al. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Biochemistry. 1986. doi:10.1021/bi00357a018

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: F12 · Klkb1 · F9 · Kng1