Conventional / global / constitutive KO
●3 Models Available
F11 Conditional Knockout, Knockout mouse models
Browse 3 F11 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as F11 conditional knockout mouse, F11 knockout mouse. Contact us for availability and fast turnaround.
Why model F11
Mouse F11, ortholog of human F11, encodes coagulation factor XI, a disulfide-linked homodimer in which each subunit contributes four apple domains and a trypsin-like catalytic domain; the apple modules dock high molecular weight kininogen, platelet GPIb, heparin, and the substrate factor IX. Factor XI is activated by factor XIIa during contact activation or, more relevant in vivo, by thrombin feedback on polyanionic surfaces, and factor XIa then cleaves factor IX to sustain intrinsic tenase and thrombin amplification. The therapeutic appeal is asymmetry: human factor XI deficiency causes only injury-related bleeding while mouse nulls are protected from arterial and venous thrombosis, uncoupling hemostasis from pathological clotting and underpinning abelacimab and milvexian development. Nulls are viable, so a conditional allele is not strictly required, though hepatocyte-restricted deletion clarifies the source. Humanized knockins are the appropriate design when antibodies or small molecules targeting human apple domains or the catalytic pocket are being tested.
What F11 mouse models are available?
ingenious targeting laboratory offers 3 distinct F11 (F11) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F11 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F11 allele types
Knockout, conditional, knockin, humanized, and related paths for F11 (human F11). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F11 catalog models
3 F11 lines with QC documentation and technical support. F11 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a F11 mouse model?
We have 3 F11 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F11 Mouse Model Types
A F11 knockout mouse has the F11 gene permanently inactivated, enabling loss of function studies. A F11 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of F11, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for F11 organized by modification type. Each URL is indexable and matches common search patterns.