FCGRT Mouse Models

Why Model FCGRT

Fcgrt is the mouse ortholog of human FCGRT and encodes the neonatal Fc receptor (FcRn), an MHC class I-like receptor that binds IgG and albumin. FcRn has been associated with recycling and extended half-life of IgG and albumin and with transfer of IgG across cellular barriers.

FcRn blockade reduces circulating IgG and is used in antibody-mediated autoimmune diseases; FcRn also influences the pharmacokinetics of therapeutic antibodies. Fcgrt-deficient mice show reduced IgG and albumin half-life.

Model Applications

Humanized FCGRT (FcRn) models, often combined with human albumin or IgG components, have been used to study antibody and albumin pharmacokinetics and to evaluate FcRn-directed agents in defined experimental settings.

Custom FCGRT Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Neonatal Fc receptor — biology and therapeutics. N Engl J Med. 2025. doi:10.1056/nejmra2312718
• Story CM et al. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J Exp Med. 1994. doi:10.1084/jem.180.6.2377

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: B2m · Fcgr2b · Alb · Lrp2