Flt3 Mouse Models

Why Model Flt3

Flt3 is the mouse ortholog of human FLT3 and encodes FLT3 (CD135), a class III receptor tyrosine kinase expressed on hematopoietic progenitor cells. Binding of FLT3 ligand promotes signaling that has been associated with proliferation and survival of early progenitors.

Activating FLT3 mutations, including internal tandem duplications, have been associated with acute myeloid leukemia, and FLT3 inhibitors are used in FLT3-mutated disease; resistance can emerge. Flt3-deficient mice are viable with reduced numbers of certain progenitor populations.

Model Applications

Humanized FLT3 models, in which the human receptor replaces the mouse counterpart, have been used to evaluate FLT3-targeted agents.

Flt3 models have been used to study hematopoiesis and FLT3-driven leukemia in defined experimental settings.

Custom Flt3 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• A systematic review of second-generation FLT3 inhibitors for treatment of patients with relapsed/refractory acute myeloid leukemia. Leuk Res. 2024. doi:10.1016/j.leukres.2024.107505
• Small D et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A. 1994. doi:10.1073/pnas.91.2.459

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Flt3lg · Kit · Csf1r · Npm1