What Flt3 Conditional Knockout mouse models are available?

When Flt3 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Flt3 knockout embryonic lethal in mice?

It depends on background and allele design. Some Flt3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Flt3 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Flt3?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●11 Models Available

READY TO SHIP!

LIVE · SPERM · DEVELOPING

Flt3 Conditional Knockout, Knockin, Knockout mouse models

Browse 11 Flt3 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Flt3 conditional knockout mouse, Flt3 knockin mouse, Flt3 knockout mouse, Flt3 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Flt3

FMS-like tyrosine kinase 3, encoded by Flt3 and orthologous to human FLT3, is a class III receptor tyrosine kinase with five immunoglobulin-like extracellular domains, a juxtamembrane autoinhibitory segment, and a split kinase domain, driving STAT5, RAS/MAPK, and PI3K signaling upon FLT3 ligand binding on multipotent and lymphoid progenitors. Internal tandem duplications within the juxtamembrane region relieve autoinhibition and impose constitutive, mislocalized STAT5 activation, while tyrosine kinase domain substitutions at D835 confer a distinct active conformation and differing sensitivity to type I versus type II inhibitors. Because a straightforward null is viable with only modest progenitor deficits, informative cancer models use knockin ITD alleles, which produce myeloproliferative disease and cooperate with Npm1 or Dnmt3a mutations to yield frank leukemia. Ectodomain humanization supports antibody, bispecific, and CAR-T evaluation. Select allele class according to whether the endpoint is inhibitor resistance, cooperating mutation genetics, or immunotherapy targeting.

What Flt3 mouse models are available?

ingenious targeting laboratory offers 11 distinct Flt3 (FLT3) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
11 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Flt3 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
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Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Flt3 allele types

Knockout, conditional, knockin, humanized, and related paths for Flt3 (human FLT3). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO

Inducible conditional KO

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI

Tag KI

Conditional KI

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Targeted Transgenic

Safe harbor

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre

Tamoxifen or dox inducible Cre

Dual recombinase

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Gene specific reporter knockin

Standalone reporter catalog

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Available Flt3 catalog models

11 Flt3 lines with QC documentation and technical support. Flt3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Flt3-Flox
CKO
CKO
These strains carry loxP sites flanking exon 2 of Flt3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Flt3 gene.
Sperm CryopreservedCKO 231301
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Flt3-ITD
KI
Other
18bp ITD mutation expression cassette was knocked into the Flt3 gene .
Sperm CryopreservedKI 230028
Order
Flt3-2A-CreERT2
KI
Cre/Dre Toolbox
The 2A-CreERT2 expression cassette was knocked into the Flt3 gene stop codon site.
Sperm CryopreservedKI 231796
Order
Flt3-2A-Cre
KI
Cre/Dre Toolbox
The 2A-Cre expression cassette was knocked into the Flt3 gene stop codon site.
Sperm CryopreservedKI 234591
Order
Flt3-2A-DreERT2
KI
Cre/Dre Toolbox
A 2A-DreERT2 expression cassette was knocked into the Flt3 gene stop codon site.
Sperm CryopreservedKI 190115
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Flt3-KO
KO
KO
This Flt3 knockout mouse model was generated by knocking out the exon 4 region of the Flt3 .
Sperm CryopreservedKO 190082
Order
Flt3-KO(M-NSG)
KO
KO, Immunodeficient
The exon3 of Flt3 gene was deleted to generate Flt3 knockout mouse.
LiveKO 234079
Order
Flt3-KO(2)
KO
KO
The exon 2 of Flt3 gene was deleted to generate Flt3 knockout mouse.
Sperm CryopreservedKO 251287
Order
Flt3-KO/IL2rg/Rag2/hSIRPA(BALB/c)
XA
Target-Humanized
The hSIRPA(BALB/c,2) (HU 210369) was crossed with Rag2/IL2rg/Flt3-KO(BALB/c)(KO 234080) to generate hSIRPA(BALB/c,2)/Rag2/IL2rg/Flt3-KO(BALB/c) mice.
In DevelopmentXA 263622
Order
Flt3-KO/hFLT3LG(M-NSG)
XA
KO, Target-Humanized, Immunodeficient
The Flt3-KO(NMG) (KO 234079) was crossed with hFLT3LG(NMG)(HU 242455) to generate Flt3-KO(NMG)/hFLT3LG(NMG) mice.
LiveXA 252200
Order
Flt3-KO/hFLT3LG/hIL15-TgV1(M-NSG)
XA
KO, Target-Humanized, Immunodeficient, Random Transgenic
The hIL15-TgV1(NMG) (KI 220133) was crossed with Flt3-KO/hFLT3LG(NMG)(XA 252200) to generate Flt3-KO/hFLT3LG/hIL15-TgV1(NMG) mice.
LiveXA 254114
Order

Looking for a Flt3 mouse model?

We have 11 Flt3 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

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Included

QC Documentation

About Flt3 Mouse Model Types

A Flt3 knockout mouse has the Flt3 gene permanently inactivated, enabling loss of function studies. A Flt3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Flt3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Flt3 knockin models carry a precisely inserted sequence at the Flt3 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Flt3 organized by modification type. Each URL is indexable and matches common search patterns.

Flt3 Conditional Knockout Flt3 Knockin Flt3 Knockout Flt3 Xenograft-Applicable Flt3 cDNA Knockin Flt3 Epitope Tag Knockin Flt3 Humanized Flt3 Inducible Knockout Flt3 Reporter

Related Gene Targets

Flt1 Flt3l Flt4

Breed this line with ingenious targeting laboratory

Send the Flt3 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Live colonies

Flt3 models ready to ship

Get a confirmed quote in 24 hours. All Flt3 models ship with full QC documentation, health certificates, and lifetime technical support.

Flt3Study ready strains in catalog

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Model generation

Need a knockout, knockin, or humanized line?

Specialized conventional and conditional knockouts
Knockins including point mutations, cDNA insertions, and epitope tags
Humanized models, including partial and full gene replacements
Targeted transgenesis in safe harbor loci
Inducible/reversible alleles using advanced recombinase techniques

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 2,800+ custom models generated since 1998. 100% germline transmission guarantee.

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