What Flt3 Conditional Knockout mouse models are available?

When Flt3 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Flt3 knockout embryonic lethal in mice?

It depends on background and allele design. Some Flt3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Flt3 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Flt3?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●9 Models Available

Flt3 Conditional Knockout, Knockin, Knockout mouse models

Browse 9 Flt3 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Flt3 conditional knockout mouse, Flt3 knockin mouse, Flt3 knockout mouse, Flt3 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Flt3

FMS-like tyrosine kinase 3, encoded by Flt3 and orthologous to human FLT3, is a class III receptor tyrosine kinase with five immunoglobulin-like extracellular domains, a juxtamembrane autoinhibitory segment, and a split kinase domain, driving STAT5, RAS/MAPK, and PI3K signaling upon FLT3 ligand binding on multipotent and lymphoid progenitors. Internal tandem duplications within the juxtamembrane region relieve autoinhibition and impose constitutive, mislocalized STAT5 activation, while tyrosine kinase domain substitutions at D835 confer a distinct active conformation and differing sensitivity to type I versus type II inhibitors. Because a straightforward null is viable with only modest progenitor deficits, informative cancer models use knockin ITD alleles, which produce myeloproliferative disease and cooperate with Npm1 or Dnmt3a mutations to yield frank leukemia. Ectodomain humanization supports antibody, bispecific, and CAR-T evaluation. Select allele class according to whether the endpoint is inhibitor resistance, cooperating mutation genetics, or immunotherapy targeting.

What Flt3 mouse models are available?

ingenious targeting laboratory offers 9 distinct Flt3 (FLT3) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
9 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Flt3 model types

PathAvailability

Knockout
View catalog
Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Flt3 allele types

Knockout, conditional, knockin, humanized, and related paths for Flt3 (human FLT3). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Flt3 catalog models

9 Flt3 lines with QC documentation and technical support. Flt3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Flt3-Flox
Conditional Knockout
KO/CKO mice
sperm cryopreservationCKO 231301
Order
Flt3-2A-DreERT2
Knockin
Cre/Dre Toolbox of Mice
sperm cryopreservationKI 190115
Order
Flt3-2A-Cre
Knockin
Cre/Dre Toolbox of Mice
sperm cryopreservationKI 234591
Order
Flt3-2A-CreERT2
Knockin
Cre/Dre Toolbox of Mice
sperm cryopreservationKI 231796
Order
Flt3-ITD
Knockin
other
sperm cryopreservationKI 230028
Order
Flt3-KO(2)
Knockout
KO/CKO mice
sperm cryopreservationKO 251287
Order
Flt3-KO(M-NSG)
Knockout
KO/CKO mice, Immunodeficient mice
sperm cryopreservationKO 234079
Order
Flt3-KO
Knockout
KO/CKO mice
liveKO 190082
Order
Flt3-KO/hFLT3LG(M-NSG)
Xenograft-Applicable
KO/CKO mice, Target humanized mice, Immunodeficient mice
liveXA 252200
Order

Looking for a Flt3 mouse model?

We have 9 Flt3 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Flt3 Mouse Model Types

A Flt3 knockout mouse has the Flt3 gene permanently inactivated, enabling loss of function studies. A Flt3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Flt3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Flt3 knockin models carry a precisely inserted sequence at the Flt3 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Flt3 organized by modification type. Each URL is indexable and matches common search patterns.

Flt3 Conditional Knockout Flt3 Knockin Flt3 Knockout Flt3 Xenograft-Applicable Flt3 cDNA Knockin Flt3 Epitope Tag Knockin Flt3 Humanized Flt3 Inducible Knockout Flt3 Reporter

Related Gene Targets

Flt1 Flt3l Flt4