Folh1 Mouse Models

Why Model Folh1

Folh1 is the mouse ortholog of human FOLH1 and encodes prostate-specific membrane antigen (PSMA), a transmembrane glutamate carboxypeptidase. PSMA has been associated with folate and glutamate metabolism and is expressed in prostate epithelium and some other tissues.

PSMA is highly expressed on most prostate cancers, and PSMA-directed imaging and radioligand therapies are used clinically. Folh1-deficient mice are viable under standard conditions.

Model Applications

Humanized FOLH1 (PSMA) models, in which the human protein replaces the mouse counterpart, have been used to evaluate PSMA-directed imaging and therapeutic agents in defined experimental settings.

Custom Folh1 Model Options

Engineered to your specifications, with molecular validation of the targeted allele and germline transmission guaranteed.

• Conventional knockout
• Conditional knockout
• Point mutation / knockin
• Reporter knockin
• Humanized
• Targeted transgenic

Sources

• Diagnostic performance of PSMA PET for the detection of prostate cancer and primary staging before definitive treatment: a systematic review and meta-analysis. Eur Urol. 2025. doi:10.1016/j.eururo.2025.03.003
• Carter RE et al. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc Natl Acad Sci U S A. 1996. doi:10.1073/pnas.93.2.749

Last reviewed: October 22, 2026 · Reviewed by: Paul Sheiffele

Related gene targets: Folr1 · Naalad2 · Klk3 · Steap1